Insights
Notes from the supply side of the bench.
Short, practical writing for research scientists working with exosome and stem cell preparations — what to ask suppliers for, what each per-lot data point actually tells you, and how to keep a multi-month protocol from stalling on lot-to-lot variability.
Why characterized EV preparations matter for research reproducibility
Particle counts alone do not tell you whether two batches of exosomes are equivalent. Here is the per-lot data envelope to look for before you commit a six-month protocol to a supplier.
Read →A practical primer on MSC identity and the ISCT minimum criteria
The 2006 ISCT position paper is still the working definition for what counts as a mesenchymal stem cell preparation. Here is what each of the three criteria actually requires on a Certificate of Analysis.
Read →Mitochondrial activity as a quality signal in stem cell preparations
Membrane potential, ATP yield, and mitochondrial mass are not just biology — they are quality-control signals that often predict downstream functional performance. What to ask your supplier for.
Read →Fresh vs. cryopreserved: what changes and what to test for
Cryopreservation is not a no-op. Even with optimal protocols, post-thaw populations differ from freshly isolated cells in measurable ways. Here is what to characterize before drawing conclusions.
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